PREVALENCE OF ANTHELMINTIC RESISTANCE IN CATTLE GASTROINTESTINAL NEMATODES AND RISK FACTORS: A SYSTEMATIC REVIEW-META-ANALYSIS APPROACH
Autor(es): America Mederos, Beatriz Carracelas, Alessandro Pelegrine Minho, Silvina Fernández, Javier Sánchez
PREVALENCE OF ANTHELMINTIC RESISTANCE IN CATTLE GASTROINTESTINAL NEMATODES AND RISK FACTORS: A SYSTEMATIC REVIEW-META-ANALYSIS APPROACH
» Área de pesquisa: HELMINTOLOGIA
» Instituição: Embrapa
» Agência de fomento e patrocinadores:
A systematic review-meta-analysis was carried out with the aim of obtain evidence of the prevalence of anthelmintic resistance in cattle gastrointestinal nematodes and the potential risk factors for its development. A search algorithm was constructed and a comprehensive search of the primary literature was conducted in: CAB abstract (1990-2012), Medline (1860-2012), Agricola (1924-2012) and Lilacs (1985-2012). Additional studies were identified by hand searching proceedings and bibliographies of recent articles reviews. Prevalence estimates were combined through meta-analysis (MA) using the logit prevalence and between-study heterogeneity was quantified Twenty-six publications (5 cross-sectional studies; 11 prevalence surveys and 10 clinical trials) were included in the review. Random effect MA resulted in an overall logit prevalence back-transformed of 70.0% (95%CI=58.4% to 79.5%) with high heterogeneity (I2=56.9%). A subgroups analysis showed that when stratifying studies by high (P>50%) and low (P<=50%) prevalence, the between study heterogeneity was reduced. For the group of studies with high prevalence, the I2 was 12.8% (p=0.287) and for the low prevalence the I2 was 0.0% (p=0.536).From studies reporting the nematode genera involved in the AR, Cooperia spp was present in 90.5% of the studies (n=21); Ostertagia sp. in 40.0% (n=20); Haemonchus sp. in 40.0% (n=20); Trichostrongylus sp. in 20.0% (n=20) and Oesophagostomum spp. in 30.0% (n=20).The included cross sectional studies suggested that frequency of treatments, age of cattle and managements are some potential risk factors associated with cattle GINs AR presence. However, more detailed studies are necessary to fully evaluate risk factors to implement sustainable GINs control strategies.
